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TAS7500

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TAS7500

Terahertz Spectroscopic / Imaging System TAS7500


The TAS7500 (*) is a compact and multipurpose nondestructive spectral imaging analysis system that fully utilizes the properties of terahertz (THz) waves. The coating and internal properties of pharmaceutical tablets are analyzed and visualized in 2D and 3D. In addition, spectrometry tailored to various dosage forms - from liquids to solids - and the analysis of physicochemical properties are made possible by simply exchanging the measurement module. Through the system Advantest is contributing to pharmaceutical product quality from the drug formulation stage to the scale-up stage.
(*) This system was developed by Advantest in collaboration with Prof. Dr. Katsuhide Terada of Toho University.


Features

Nondestructive imaging of internal structure of tablets

The TAS7500 nondestructively visualizes the distributions of physical and chemical properties in 2D and 3D. Film thickness and density variations of tablets are a complex system that determines product performance. The user interface allows development of highly automated methods for a wide variety of measurements and analyses of samples.

Rapid, flexible, automated analysis of various pharmaceutical dosage forms

The TAS7500 analyzes spectral properties of complex dosage forms based on intermolecular interactions. Rapid analysis of physicochemical properties of various dosage forms - from liquids to solids - is possible by simply exchanging measurement modules (transmission, reflection, and ATR).

Automated, high-throughput, compact and multifunctional System

Advantest has created a multifunctional and modular spectroscopic system that enables operations ranging from imaging analysis to various spectral analysis in a compact, table-top sized format. High-throughput measurement and analysis is possible with Advantestfs unique high-performance THz autosampler.


TAS7500 system configuration




Specifications

Primary Specifications of TAS7500
Primary measurement applications

Nondestructive 2D or 3D measurement of defects by THz
(Imaging analysis mode)

THz spectral measurements
(transmission mode/reflection mode/ATR mode)
Measurement target
• Specimen:
 Medicinal tablets, pharmaceutical products (powders, liquids), other reagents, chemical substances
• Specimen dimensions:

Tablet defect analysis mode:
less than 20 mm diameter, 10 mm thickness;

weight: less than 50 g

Penetration/reflection mode:
5 mm - 300 mm square, less than 10 mm thickness

ATR mode:
5 mm diameter (powder, liquid), 5 mm - 20 mm square, less than 10 mm thickness (solid)
Imaging function (tablet analysis)
• Spatial resolution:
 0.3 mm (at 2 THz)
• minimum step size for mechanical translation stage
 0.05 mm
• Automatic measurement
 Place up to 10 tablets in a dedicated cassette and execute automatic measurements
Analysis/display function
  • Spectral display (transmittance, reflectance, absorbance, absorption coefficient, complex refractive index)
  • Time waveform display (electric field strength, electric field reflection strength)
  • 1D mapping display (tomogram)
  • 2D mapping display (thickness, density, interface condition, optical spectrum)
  • 3D mapping display (thickness, density, interface condition)
Measurement performance
• Maximum frequency range:
 0.05 - 4 THz, extension to 7 THz available as an optional feature
(in transmission or reflection mode, S/N = 1) (*1)
• S/N:
 50 dB or more (average 1024 at peak frequency) (*1)
• Thickness measurement performance
 Measurement scope: over 30 µm; resolution: 2 µm
Throughput:
 Spectrometry: max. 3.3 ms/scan; imaging measurement: within 5 min (32×32 points, average 32 times)
Purge:
 Built-in dry air filter (external air supply required)

General specifications
Usage Environment:
 Temperature range: +10 °C to +30 °C;
relative humidity: under 80% (non-condensing conditions)
Power:
 AC 100 V (100-120) / 200 V (220-240), 500 VA, 50/60 Hz (*2)
External dimensions/mass
• Imaging measurement unit:
 dimensions: 495 (W) × 490 (D) × 380 (H) mm;
mass: less than 38 kg
• Spectroscopic measurement unit:
 dimensions: 400 (W) × 490 (D) × 380 (H) mm;
mass: less than 21 kg
(*1) Temperature range 23±5 °C
(*2) Excluding analysis PC